The strategic competition between Israel and Iran, parallel to a new American administration taking the helm, have constituted core meta-forces shaping the Middle Eastern arena in the past year. Along with this, the volatile state of the Palestinian arena in the Gaza Strip and Judea and Samaria; Hezbollah’s progress in force design and particularly progress on its precision project; the end of the civil war in Syria and entrenchment of the Iranian and Russian presence in Syria; regional competition over energy resources and influence in the Mediterranean Basin; the deep economic crisis in Lebanon; the Covid pandemic; escalating regional economic crisis; and the return globally of the Jihadist challenge with the withdrawal of the United States from Afghanistan underscore the scope of change in the region, and its implications for Israel’s national security.